Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.41 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533458 | 0.92 | HPGDS (0.46) | TTBK1TTBK2JAK2JAK1JAK3 | |
| SCHEMBL193515 | 0.79 | AURKA (0.57) | AURKARPS6KB1TTBK1TTBK2EGFR | |
| SCHEMBL6746641 | 0.79 | AURKA (0.57) | AURKARPS6KB1TTBK1TTBK2EGFR | |
| SCHEMBL3535943 | 0.77 | TTBK1 (0.49) | TTBK1TTBK2JAK2JAK1HPGDS | |
| SCHEMBL7848314 | 0.75 | JAK3 (0.51) | PDPK1JAK2JAK1JAK3TYK2 | |
| SCHEMBL8930214 | 0.73 | AURKA (0.59) | AURKARPS6KB1TTBK1TTBK2EGFR | |
| Hydrochloric Acid SCHEMBL8929656 | 0.72 | AURKA (0.58) | AURKARPS6KB1TTBK1TTBK2EGFR | |
| SCHEMBL12561873 | 0.70 | JAK2 (0.61) | TTBK1TTBK2JAK2JAK1HPGDS | |
| SCHEMBL61508 | 0.69 | PDPK1 (1.00) | PDPK1 | |
| SCHEMBL29395031 | 0.69 | PDPK1 (1.00) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087970-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065908-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |