Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 17/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417927 | 0.90 | FBP1 (0.61) | FBP1EGFRHDAC3KDRHDAC4 | |
| SCHEMBL7848130 | 0.89 | FBP1 (0.60) | FBP1EGFRHDAC3KDRHDAC4 | |
| SCHEMBL3574352 | 0.86 | FBP1 (0.69) | FBP1EGFRKDR | |
| SCHEMBL1417823 | 0.86 | FBP1 (0.60) | FBP1EGFRHDAC3KDRHDAC4 | |
| SCHEMBL1418159 | 0.84 | FBP1 (0.64) | FBP1EGFRHDAC3KDRHDAC4 | |
| SCHEMBL1418029 | 0.83 | FBP1 (0.62) | FBP1EGFRKDR | |
| SCHEMBL3584717 | 0.83 | FBP1 (0.68) | FBP1EGFRKDR | |
| SCHEMBL1417871 | 0.82 | FBP1 (0.68) | FBP1EGFRKDR | |
| SCHEMBL1417778 | 0.81 | FBP1 (0.63) | FBP1EGFRHDAC3KDRHDAC4 | |
| SCHEMBL1419005 | 0.79 | FBP1 (0.62) | FBP1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |