Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 14/20 | 0.55 |
| ▸ | GABRD | O14764 | 14/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 14/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 14/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 14/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 14/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 14/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 14/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 14/20 | 0.55 |
| ▸ | GABRE | P78334 | 14/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 14/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 14/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 14/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 14/20 | 0.55 |
| ▸ | HTR1B | P28222 | 6/20 | 0.41 |
| ▸ | HTR1D | P28221 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848727 | 1.00 | GABRP (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7366011 | 0.86 | GABRP (0.68) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7366014 | 0.86 | GABRP (0.68) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7367554 | 0.79 | GABRP (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7367559 | 0.79 | GABRP (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7852359 | 0.78 | GABRP (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7368046 | 0.75 | HTR1D (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8885806 | 0.75 | SLC6A4 (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8473966 | 0.74 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7367560 | 0.73 | HTR1A (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |