Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846025 | 0.86 | IKBKB (0.72) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL30968554 | 0.84 | MAPT (0.54) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL20722662 | 0.84 | MAPT (0.54) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL7837105 | 0.84 | MAPT (0.54) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL31167190 | 0.84 | MAPT (0.54) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL31167168 | 0.81 | ALDH1A1 (0.51) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL19212108 | 0.81 | KDM4E (0.51) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL7848995 | 0.77 | ALDH1A1 (0.50) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL2896095 | 0.75 | IKBKB (0.68) | MAPTKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22957499 | 0.74 | KDM4E (0.63) | MAPTKDM4EALDH1A1SMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942911-B1 | BENZOPYRANOPYRROLE AND BENZOPYRANOPYRIDINE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LAB (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6046207-A | FOR INHIBITING ALPHA-1 ADRENORECEPTORS AND TREATING BENIGN PROSTATIC HYPERPLASIA, ALSO CALLED BENIGN PROSTATIC HYPERTROPHY, OR OTHER UROLOGICAL OR GYNECOLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION, NEUROGENIC BLADDER | ABBOTT LABORATORIES | 2000-04-04 | — | — | US | disclosed |
| US-5891882-A | TREATING BENIGN PROSTATIC HYPERPLASIA OR OTHER UROLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION AND NEUROGENIC BLADDER, OR GYNECOLOGICAL SYNDROMES SUCH AS DYSMENORRHEA | ABBOTT LABORATORIES (US) | 1999-04-06 | — | — | US | disclosed |