Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.49 |
| ▸ | NMBR | P28336 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | CCKBR | P32239 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849423 | 0.88 | TACR1 (0.46) | TACR1NMBRCCKBRMEN1NPC1 | |
| SCHEMBL7067889 | 0.85 | TACR1 (0.56) | TACR1NMBR | |
| SCHEMBL7847648 | 0.82 | CCKBR (0.53) | TACR1NMBRCCKBRMEN1NPC1 | |
| SCHEMBL7855382 | 0.81 | TACR1 (0.51) | TACR1NMBRCCKBRMEN1NPC1 | |
| SCHEMBL7061471 | 0.81 | TACR1 (0.53) | TACR1NMBRCCKBRMEN1NPC1 | |
| SCHEMBL13524867 | 0.81 | TACR1 (0.55) | TACR1NMBRCCKBRMEN1NPC1 | |
| SCHEMBL13525369 | 0.80 | TACR1 (0.55) | TACR1NMBRCCKBRMEN1NPC1 | |
| SCHEMBL6251420 | 0.80 | TACR1 (0.49) | TACR1NMBR | |
| SCHEMBL7062980 | 0.80 | TACR1 (0.57) | TACR1NMBRCCKBRMEN1NPC1 | |
| SCHEMBL8829903 | 0.79 | NMBR (0.60) | NMBRBCHECCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140914-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037462-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |