Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847345 | 0.90 | ACHE (0.43) | CHRM4KDM4EPKMPRMT5WDR77 | |
| SCHEMBL7849387 | 0.85 | GPR119 (0.55) | CHRM4GPR119 | |
| SCHEMBL7847536 | 0.84 | ACHE (0.58) | ACHE | |
| SCHEMBL7847033 | 0.84 | GPR119 (0.61) | CHRM4ACHEGPR119 | |
| Hydrochloric Acid SCHEMBL7846888 | 0.84 | ACHE (0.57) | ACHE | |
| SCHEMBL7848891 | 0.83 | GPR119 (0.48) | GPR119NPC1RAB9A | |
| SCHEMBL7850437 | 0.83 | GPR119 (0.46) | GPR119NPC1RAB9A | |
| SCHEMBL7855571 | 0.81 | GPR119 (0.52) | CHRM4KDM4EPKMGPR119STS | |
| SCHEMBL7838242 | 0.81 | CHRM4 (0.44) | CHRM4KDM4EPKMPRMT5WDR77 | |
| SCHEMBL8444736 | 0.80 | KDM4E (0.59) | KDM4EPKMGPR119THRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1122252-A1 | NITROGENOUS FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2001-08-08 | — | — | EP | disclosed |