Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.46 |
| ▸ | GAK | O14976 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.46 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28133700 | 0.81 | ERBB2 (0.71) | ERBB2HTTMAPKAPK2GAKRIPK2 | |
| SCHEMBL1387165 | 0.81 | ERBB2 (1.00) | ERBB2HTTGAKRIPK2COQ8A | |
| Hydrochloric Acid SCHEMBL8812168 | 0.79 | ERBB2 (0.97) | ERBB2HTTGAKRIPK2COQ8A | |
| SCHEMBL10000194 | 0.78 | ERBB2 (0.94) | ERBB2HTTGAKRIPK2COQ8A | |
| SCHEMBL2595327 | 0.77 | ERBB2 (0.64) | ERBB2HTTMAPKAPK2GAKRIPK2 | |
| SCHEMBL15607515 | 0.76 | ERBB2 (0.58) | ERBB2HTTMAPKAPK2GAKRIPK2 | |
| SCHEMBL5948717 | 0.76 | ERBB2 (0.66) | ERBB2HTTMAPKAPK2GAKKDR | |
| SCHEMBL8809979 | 0.76 | FGFR2 (0.72) | ERBB2HTTGAKRIPK2COQ8A | |
| SCHEMBL15607661 | 0.76 | ERBB2 (0.56) | ERBB2HTTMAPKAPK2GAKRIPK2 | |
| Hydrochloric Acid SCHEMBL8933873 | 0.75 | FGFR2 (0.70) | ERBB2HTTGAKRIPK2COQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719831-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| US-20030219427-A1 | TPL-2/COT kinase and methods of use | MEDICAL RESEARCH COUNCIL (GB) | 2003-11-27 | — | — | US | claimed |
| JP-2002531058-A | — | — | 2002-09-24 | — | — | JP | claimed |
| US-20020099169-A1 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLCHAFT | 2002-07-25 | — | — | US | claimed |
| EP-1105501-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF Aktiengesellschaft (US) | 2001-06-13 | — | — | EP | claimed |
| WO-2000011191-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLSCHAFT (US) | 2000-03-02 | — | — | WO | claimed |
| US-20030219427-A1 | TPL-2/COT kinase and methods of use | MEDICAL RESEARCH COUNCIL (GB) | 2003-11-27 | — | — | US | disclosed |
| US-20020099169-A1 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLCHAFT | 2002-07-25 | — | — | US | disclosed |
| EP-1105501-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF Aktiengesellschaft (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000011191-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLSCHAFT (US) | 2000-03-02 | — | — | WO | disclosed |