Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8505950 | 0.91 | TLR7 (0.49) | DHODHKDM4ETLR7PTGESALOX5 | |
| SCHEMBL7838473 | 0.90 | NR1H4 (0.49) | DHODHKDM4ECYSLTR1AGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL8502040 | 0.89 | NR1H4 (0.48) | DHODHKDM4ECYSLTR1AGTR1AGTR2 | |
| SCHEMBL7839574 | 0.83 | KDM4E (0.50) | DHODHKDM4ECYSLTR1AGTR1AGTR2 | |
| SCHEMBL9182577 | 0.83 | KDM4E (0.56) | KDM4EAGTR1AGTR2 | |
| SCHEMBL8672079 | 0.83 | KDM4E (0.53) | DHODHKDM4E | |
| Hydrochloric Acid SCHEMBL8504756 | 0.82 | KDM4E (0.49) | DHODHKDM4ECYSLTR1AGTR1AGTR2 | |
| SCHEMBL9119796 | 0.81 | DHODH (0.53) | DHODHKDM4EAGTR1AGTR2RARB | |
| SCHEMBL7849442 | 0.80 | RXRA (0.43) | CYSLTR1PTGESALOX5PPARGPDE4A | |
| SCHEMBL8505737 | 0.77 | DHODH (0.55) | DHODHAGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498723-B1 | Nitrogen containing bicycle compounds, method for their preparation, their use as pharmaceutical and compositions containing them | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |
| US-6004979-A | ANGIOTENSIN II INHIBITORS; 4-((CARBOXY)ARYLOXY)-QUINOLINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |
| EP-0498723-A1 | Nitrogen containing bicycle compounds, method for their preparation, their use as pharmaceutical and compositions containing them | ROUSSEL UCLAF (FR) | 1992-08-12 | — | — | EP | disclosed |