Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6809616 | 0.99 | ACKR3 (0.44) | ACKR3KDM4EABHD6POLBROCK1 | |
| SCHEMBL6804230 | 0.77 | POLB (0.44) | POLBRAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL4918174 | 0.72 | HSD17B2 (0.70) | ACKR3HSD17B2HDAC1HDAC3HSD17B1 | |
| SCHEMBL6808781 | 0.70 | MAPK14 (0.47) | KDM4EROCK1JAK2MAPTHDAC1 | |
| SCHEMBL6799622 | 0.70 | JAK2 (0.43) | KDM4EPOLBROCK1JAK2RAB9A | |
| SCHEMBL15263998 | 0.66 | ABHD6 (0.69) | ABHD6 | |
| SCHEMBL11331200 | 0.66 | MAPT (0.53) | ABHD6POLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6799201 | 0.65 | GABRA1 (0.36) | ACKR3KDM4EABHD6POLBROCK1 | |
| SCHEMBL6801935 | 0.65 | MAPK1 (0.42) | KDM4EPOLBJAK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL5182572 | 0.65 | NR1H2 (0.50) | ALDH1A1ALOX15HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853083-B1 | Pyridylfuran and pyridylthiophene compounds and pharmaceutical use thereof | PFIZER (US) | 2001-09-12 | — | — | EP | claimed |