SCHEMBL7849700

SCHEMBL7849700

CCOC(=O)NC(=S)Nc1ncc(C(F)(F)F)cc1F

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.51
▸ L3MBTL1 Q9Y468 2/20 0.48
▸ RECQL P46063 1/20 0.47
▸ PKM P14618 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ GAA P10253 3/20 0.46
▸ POLB P06746 3/20 0.46
▸ MAPT P10636 1/20 0.45
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ KDM4E B2RXH2 3/20 0.42
▸ ALDH1A1 P00352 4/20 0.42
▸ HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11749064 0.88 LMNA (0.51) LMNAL3MBTL1RECQLPKMTDP1
SCHEMBL27038718 0.85 MAPT (0.43) LMNARECQLPKMMAPTMEN1
SCHEMBL30699232 0.85 MAPT (0.43) LMNARECQLPKMMAPTMEN1
SCHEMBL27037825 0.79 GAA (0.66) LMNAL3MBTL1GAAPOLBMAPT
SCHEMBL18952659 0.77 MAPT (0.41) LMNAL3MBTL1RECQLPKMTDP1
SCHEMBL26961993 0.77 MAPT (0.44) LMNAL3MBTL1GAAPOLBMAPT
SCHEMBL30675731 0.77 MAPT (0.44) LMNAL3MBTL1GAAPOLBMAPT
SCHEMBL23030187 0.76 MAPT (0.49) LMNAL3MBTL1PKMMAPTMEN1
SCHEMBL31489368 0.76 MAPT (0.44) LMNAL3MBTL1PKMMAPTMEN1
SCHEMBL18952507 0.75 MAPT (0.43) LMNAGAAMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0717743-B1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 2001-11-14 — — EP disclosed
EP-0972774-A2 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines Dow AgroSciences LLC (US) 2000-01-19 — — EP disclosed
US-5700940-A FOR PRE- OR POSTEMERGENCE SPRAYING OF PLANTS OR SOILS DOWELANCO (US) 1997-12-23 — — US disclosed
US-5571775-A EFFECTIVE ON A BROAD SPECTRUM OF VEGETATION AT LOW APPLICATION RATES DOWELANCO (US) 1996-11-05 — — US disclosed
EP-0717743-A1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-06-26 — — EP disclosed
WO-1996001826-A1 N-ARYL[1,2,4]TRIAZOLO[1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-01-25 — — WO disclosed
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