Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.78 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854357 | 0.88 | MAPT (0.78) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL13973308 | 0.81 | MAPT (0.74) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL23100766 | 0.81 | HTR2A (0.57) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL23100765 | 0.81 | HTR2A (0.57) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL30425130 | 0.81 | MTNR1A (0.65) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL8241650 | 0.80 | ALDH1A1 (0.85) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL13584939 | 0.80 | MAPT (0.72) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL13584937 | 0.80 | MAPT (0.72) | MAPTHPGDRECQLCYP1A2CYP2C19 | |
| SCHEMBL7677886 | 0.79 | MEN1 (0.84) | MAPTCYP1A2CYP2C19ALDH1A1GAA | |
| SCHEMBL27099044 | 0.79 | MTNR1A (0.77) | MAPTHPGDRECQLCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140914-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037462-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |