Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | EDNRA | P25101 | 12/20 | 0.65 |
| ▸ | EDNRB | P24530 | 8/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222085 | 0.88 | EDNRA (0.67) | MEN1KMT2AEDNRAEDNRB | |
| SCHEMBL6666893 | 0.79 | NPC1 (0.74) | MEN1KMT2ACYP2C9TSHRCYP2C19 | |
| SCHEMBL12262637 | 0.78 | MAPT (0.86) | MEN1KMT2ACYP2C9TSHRCYP2C19 | |
| SCHEMBL7856711 | 0.77 | EDNRA (1.00) | MEN1KMT2AEDNRAEDNRBCYP2C9 | |
| Sulfisoxazole SCHEMBL788644 | 0.77 | EDNRA (1.00) | MEN1KMT2AEDNRAEDNRBCYP2C9 | |
| Sulfisoxazole SCHEMBL23467 | 0.77 | EDNRA (1.00) | MEN1KMT2AEDNRAEDNRBCYP2C9 | |
| SCHEMBL7860467 | 0.77 | EDNRA (1.00) | MEN1KMT2AEDNRAEDNRBCYP2C9 | |
| SCHEMBL7716850 | 0.77 | EDNRA (1.00) | MEN1KMT2AEDNRAEDNRBCYP2C9 | |
| Sulfisoxazole SCHEMBL2200933 | 0.76 | EDNRA (0.97) | MEN1KMT2AEDNRAEDNRBCYP2C9 | |
| Sulfisoxazole SCHEMBL5917298 | 0.76 | EDNRA (0.97) | MEN1KMT2AEDNRAEDNRBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069114-A2 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-01-17 | — | — | EP | claimed |
| EP-0870764-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-10-14 | — | — | EP | claimed |
| EP-1069114-A2 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |