Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15814919 | 0.87 | KDM4E (0.46) | KDM4EHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL28025942 | 0.85 | KDM4E (0.45) | KDM4EHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL3470484 | 0.83 | MEN1 (0.37) | CYP2D6ALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL27999787 | 0.82 | KDM4E (0.41) | KDM4EHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL27862787 | 0.82 | HTR2A (0.34) | HTR2CHTR2BALDH1A1 | |
| SCHEMBL29268251 | 0.81 | ALDH1A1 (0.32) | ALDH1A1KDM1A | |
| SCHEMBL28437775 | 0.81 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| Ethylene SCHEMBL27830648 | 0.81 | MEN1 (0.35) | ALDH1A1 | |
| SCHEMBL9473556 | 0.80 | CA12 (0.39) | MAPK1 | |
| SCHEMBL29152783 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035848-A4 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORP (US) | 2001-05-23 | — | — | EP | disclosed |
| EP-1035848-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORPORATION (US) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999006041-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNFα LEVELS | CELGENE CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |