Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 15/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418029 | 0.88 | FBP1 (0.62) | FBP1EGFREPHA2ERBB2RAF1 | |
| SCHEMBL1418660 | 0.88 | EGFR (0.61) | FBP1EGFREPHA2ERBB2 | |
| SCHEMBL1417927 | 0.88 | FBP1 (0.61) | FBP1EGFREPHA2KDR | |
| SCHEMBL1417823 | 0.87 | FBP1 (0.60) | FBP1EGFREPHA2KDR | |
| SCHEMBL1419005 | 0.84 | FBP1 (0.62) | FBP1EGFREPHA2ERBB2 | |
| SCHEMBL1419031 | 0.83 | FBP1 (0.61) | FBP1EGFREPHA2ERBB2KDR | |
| SCHEMBL7848642 | 0.79 | FBP1 (0.59) | FBP1EGFRKDR | |
| SCHEMBL2995000 | 0.77 | FBP1 (0.67) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL7852032 | 0.77 | FBP1 (0.67) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL3574352 | 0.75 | FBP1 (0.69) | FBP1EGFREPHA2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |