Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 3/20 | 0.34 |
| ▸ | CTSL | P07711 | 5/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849943 | 1.00 | MMP1 (0.40) | MMP1MMP13ECE1MMP3MMP8 | |
| SCHEMBL7946534 | 1.00 | MMP1 (0.40) | MMP1MMP13ECE1MMP3MMP8 | |
| SCHEMBL7847162 | 0.88 | MMP1 (0.47) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL7847158 | 0.88 | MMP1 (0.47) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL7946725 | 0.86 | MMP1 (0.42) | MMP1MMP13ECE1MMP3MMP8 | |
| SCHEMBL7946723 | 0.86 | MMP1 (0.42) | MMP1MMP13ECE1MMP3MMP8 | |
| SCHEMBL7844907 | 0.82 | L3MBTL1 (0.43) | MMP1MMP13ECE1MMP3MMP8 | |
| SCHEMBL7844905 | 0.82 | L3MBTL1 (0.43) | MMP1MMP13ECE1MMP3MMP8 | |
| SCHEMBL7841798 | 0.80 | MMP1 (0.41) | MMP1MMP13ECE1MMP3MMP8 | |
| SCHEMBL7953838 | 0.80 | MMP1 (0.41) | MMP1MMP13ECE1MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |