Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 12/20 | 0.39 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.34 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552211 | 0.82 | HRH3 (0.41) | HRH3CYP19A1GPR142CPA1FNTA | |
| SCHEMBL7826548 | 0.81 | FNTA (0.44) | HRH3CYP19A1CPA1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL7834168 | 0.80 | FNTA (0.44) | HRH3CYP19A1CPA1FNTAFNTB | |
| SCHEMBL7834674 | 0.79 | CYP19A1 (0.45) | HRH3CYP19A1CPA1FNTAFNTB | |
| SCHEMBL7826547 | 0.79 | CYP19A1 (0.46) | HRH3CYP19A1CPA1FNTAFNTB | |
| SCHEMBL7845880 | 0.77 | FNTA (0.49) | CYP19A1FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7840097 | 0.77 | FNTA (0.48) | CYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL7134263 | 0.74 | HRH3 (0.46) | HRH3CYP19A1 | |
| SCHEMBL3845496 | 0.74 | FNTA (0.53) | CYP19A1FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7484921 | 0.73 | HRH3 (0.45) | HRH3CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891349-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-01-24 | — | — | EP | disclosed |
| EP-0891349-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036888-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |