Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.81 |
| ▸ | EDNRA | P25101 | 11/20 | 0.61 |
| ▸ | CCR4 | P51679 | 8/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366024 | 0.90 | ABCB11 (1.00) | ABCB11EDNRACCR4 | |
| SCHEMBL7394736 | 0.89 | ABCB11 (0.81) | ABCB11EDNRACCR4 | |
| SCHEMBL7437540 | 0.89 | ABCB11 (0.81) | ABCB11EDNRACCR4 | |
| SCHEMBL1387204 | 0.87 | EDNRA (0.79) | ABCB11EDNRACCR4 | |
| SCHEMBL8040159 | 0.84 | EDNRA (0.62) | ABCB11EDNRACCR4 | |
| SCHEMBL7367536 | 0.83 | ABCB11 (0.67) | ABCB11EDNRA | |
| SCHEMBL7853183 | 0.83 | CCR4 (0.58) | ABCB11EDNRACCR4 | |
| SCHEMBL7367188 | 0.83 | CCR4 (0.58) | ABCB11EDNRACCR4 | |
| SCHEMBL7360038 | 0.81 | ABCB11 (0.83) | ABCB11EDNRACCR4 | |
| SCHEMBL7358563 | 0.80 | ABCB11 (0.82) | ABCB11EDNRACCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1097051-C | N-heteroaryl-pyridinesulfonamide derivatives and their use as endothelin antagonists | ZENECA LTD (GB) | 2002-12-25 | — | — | CN | claimed |
| EP-0832082-B1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-11-21 | — | — | EP | claimed |
| CN-1192739-A | N-heteroaryl-pyridinesulfonamide derivatives and their use as endothelin antagonists | ZENECA LTD (GB) | 1998-09-09 | — | — | CN | claimed |
| EP-0832082-B1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-6258817-B1 | PRODRUGS, HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | ZENECA LTD. (GB) | 2001-07-10 | — | — | US | disclosed |
| US-6060475-A | Substituted pyrazin-2-yl-sulphonamide-(3-pyridyl) compounds and uses thereof | ZENECA LIMITED (GB) | 2000-05-09 | — | — | US | disclosed |
| US-5866568-A | ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY | ZENECA LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |
| CN-1192739-A | N-heteroaryl-pyridinesulfonamide derivatives and their use as endothelin antagonists | ZENECA LTD (GB) | 1998-09-09 | — | — | CN | disclosed |