Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.62 |
| ▸ | CCR4 | P51679 | 15/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8038423 | 0.89 | ABCB11 (0.72) | EDNRACCR4ABCB11 | |
| SCHEMBL7367188 | 0.85 | CCR4 (0.58) | EDNRACCR4ABCB11 | |
| SCHEMBL7853183 | 0.85 | CCR4 (0.58) | EDNRACCR4ABCB11 | |
| SCHEMBL7850314 | 0.84 | ABCB11 (0.81) | EDNRACCR4ABCB11 | |
| SCHEMBL8038435 | 0.81 | ABCB11 (0.74) | EDNRACCR4ABCB11 | |
| SCHEMBL7398856 | 0.79 | ABCB11 (0.71) | EDNRACCR4ABCB11 | |
| SCHEMBL7362617 | 0.79 | ABCB11 (0.77) | EDNRACCR4ABCB11 | |
| SCHEMBL7365241 | 0.78 | ABCB11 (0.75) | EDNRACCR4ABCB11 | |
| SCHEMBL7359279 | 0.77 | ABCB11 (0.75) | EDNRACCR4ABCB11 | |
| SCHEMBL30296218 | 0.77 | ABCB11 (0.75) | EDNRACCR4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060475-A | Substituted pyrazin-2-yl-sulphonamide-(3-pyridyl) compounds and uses thereof | ZENECA LIMITED (GB) | 2000-05-09 | — | — | US | disclosed |
| US-5866568-A | ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY | ZENECA LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |