Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL3230312 | 0.96 | ESR2 (0.55) | ESR2DDB1CRBNCYP19A1TP53 | |
| SCHEMBL24924065 | 0.88 | PDE3B (0.46) | ESR2DDB1CRBNCYP19A1TP53 | |
| SCHEMBL14403055 | 0.84 | ESR2 (0.78) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1515255 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL9482318 | 0.78 | ESR2 (0.59) | ESR2DDB1CRBNMAPT | |
| SCHEMBL76840 | 0.77 | ESR2 (0.63) | ESR2DDB1CRBNMAPT | |
| SCHEMBL10348022 | 0.77 | ESR2 (0.69) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6419399 | 0.77 | CYP11B2 (0.54) | DDB1CRBNCYP19A1TP53SMN1; SMN2 | |
| SCHEMBL1515154 | 0.77 | CYP11B2 (0.48) | ESR2DDB1CRBNCYP19A1TP53 | |
| SCHEMBL746253 | 0.76 | CYP11B2 (0.65) | ESR2SMN1; SMN2CYP11B2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845228-A | INTERMEDIATES FOR CARDIOTONIC AGENTS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-07-04 | — | — | US | claimed |
| JP-62187455-A | — | — | None | — | — | JP | disclosed |
| JP-62126170-A | — | — | None | — | — | JP | disclosed |
| JP-62126171-A | — | — | None | — | — | JP | disclosed |
| JP-61291568-A | — | — | None | — | — | JP | disclosed |
| EP-4638442-A1 | TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS | Uniquest Pty Limited (AU) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024130342-A1 | TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS | UNIQUEST PTY LIMITED (AU) | 2024-06-27 | — | — | WO | disclosed |
| CN-107674013-B | Polycyclic compound, preparation method, pharmaceutical composition and application thereof | 上海迪诺医药科技有限公司 | 2022-05-24 | — | — | CN | disclosed |
| CN-111712490-A | Amino-substituted pyridone derivatives, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2020-09-25 | — | — | CN | disclosed |
| WO-2018028491-A1 | INDOLEAMINE2,3-DIOXYGENASE INHIBITORS AND USES THEREOF IN PHARMACY | 苏州国匡医药科技有限公司 | 2018-02-15 | — | — | WO | disclosed |
| US-4814458-A | Process for preparing 4-acetyl isoquinolinone compounds | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-03-21 | — | — | US | disclosed |
| US-4782154-A | CARDIOTONICS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1988-11-01 | — | — | US | disclosed |
| EP-0281661-A1 | 2-Alkoxycarbonyl-4-(4-pyridyl)cyclohexanones and process for preparing them | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1988-09-14 | — | — | EP | disclosed |
| EP-0236754-A1 | Novel process for preparing 4-acetyl isoquinolinone compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1987-09-16 | — | — | EP | disclosed |
| JP-S62187455-A | 4-(4-PYRIDYL)CYCLOHEXANONE-1,3-DIONE AND PRODUCTION THEREOF | MITSUI TOATSU CHEM INC | 1987-08-15 | — | — | JP | disclosed |
| JP-S62126171-A | PRODUCTION 0F 4-(4-PYRIDYL)CYCLOHEXANONE | MITSUI TOATSU CHEM INC | 1987-06-08 | — | — | JP | disclosed |
| JP-S62126170-A | PRODUCTION OF 4-(4-PYRIDYL)CYCLOHEXANONE | MITSUI TOATSU CHEM INC | 1987-06-08 | — | — | JP | disclosed |
| US-4639521-A | CARDIOTONIC AGENTS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1987-01-27 | — | — | US | disclosed |
| EP-0207500-A2 | Isoquinoline derivatives | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1987-01-07 | — | — | EP | disclosed |
| JP-S61291568-A | 2-ACYL-4-(4-PYRIDYL)CYCLOHEXANONE AND PRODUCTION THEREOF | MITSUI TOATSU CHEM INC | 1986-12-22 | — | — | JP | disclosed |