Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.35 |
| ▸ | CTSC | P53634 | 3/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 4/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230508 | 0.76 | EGFR (0.42) | SYKBTKEGFRITKKDM4E | |
| SCHEMBL6620634 | 0.70 | SYK (0.33) | SYKBTKEGFR | |
| SCHEMBL12279158 | 0.67 | BRD4 (0.56) | SYKABCG2CTSCBTKEGFR | |
| SCHEMBL1315596 | 0.66 | MAPK1 (0.44) | MAPTMAPK1 | |
| SCHEMBL30913780 | 0.66 | MAPK1 (0.42) | TP53MAPTKDM4EMAPK1 | |
| SCHEMBL6336909 | 0.64 | AURKA (0.45) | EGFRMAPTMAPK1 | |
| SCHEMBL9837406 | 0.63 | ALDH1A1 (0.37) | MAPK1 | |
| SCHEMBL501340 | 0.62 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL3599861 | 0.62 | TRPA1 (0.36) | MAPK1 | |
| SCHEMBL30913766 | 0.61 | MAPT (0.39) | MAPTKDM4EMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123295-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024744-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | disclosed |