Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853018 | 0.93 | KDM4E (0.42) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL7850569 | 0.92 | LMNA (0.49) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL7841766 | 0.91 | LMNA (0.32) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL7850852 | 0.89 | EPHA2 (0.43) | KDM4EALDH1A1LMNAPOLBHPGD | |
| Hydrochloric Acid SCHEMBL9694529 | 0.87 | CYP3A4 (0.39) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL7853014 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1LMNAPOLBHPGD | |
| Hydrochloric Acid SCHEMBL9694549 | 0.84 | EPHA2 (0.57) | KDM4EALDH1A1LMNAPOLBHPGD | |
| Hydrochloric Acid SCHEMBL9692932 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL7849611 | 0.83 | — | — | |
| SCHEMBL7854452 | 0.82 | ENPP2 (0.30) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |