Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 8/20 | 0.35 |
| ▸ | HTR2C | P28335 | 7/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680354 | 0.86 | HTR2A (0.47) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| SCHEMBL7852507 | 0.86 | MAPKAPK2 (0.45) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7673537 | 0.85 | HTR2A (0.49) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7673540 | 0.85 | HTR2A (0.49) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7683625 | 0.84 | KMT2A (0.43) | MAPKAPK2MAPKAPK5HTR2AHTR2C | |
| SCHEMBL7855196 | 0.83 | MAPKAPK2 (0.54) | MAPKAPK2MAPKAPK5HTR2AHTR2CHTR2B | |
| SCHEMBL7851653 | 0.83 | MAPKAPK2 (0.62) | MAPKAPK2SIRT1HTR2AHTR2C | |
| SCHEMBL7850944 | 0.82 | AR (0.43) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| SCHEMBL7676904 | 0.82 | SIRT1 (0.43) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| SCHEMBL7680950 | 0.82 | SIRT1 (0.54) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |