Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 2/20 | 0.44 |
| ▸ | FNTB | P49356 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838770 | 0.91 | KMT2A (0.54) | KMT2AMEN1ALOX15MAPTFNTA | |
| SCHEMBL27419359 | 0.78 | PLK1 (0.60) | KMT2AMEN1ALOX15ALDH1A1HPGD | |
| SCHEMBL11673648 | 0.77 | MEN1 (0.54) | KMT2AMEN1ALDH1A1RXFP1MAPT | |
| SCHEMBL1037260 | 0.77 | HDAC8 (0.58) | KMT2AMEN1ALOX15ALDH1A1RXFP1 | |
| SCHEMBL11550893 | 0.74 | TSHR (0.51) | KMT2AMEN1ALDH1A1RXFP1MAPT | |
| SCHEMBL16819693 | 0.73 | KDM4E (0.54) | KMT2AMEN1ALDH1A1RXFP1MAPT | |
| SCHEMBL17214429 | 0.72 | HPGD (0.60) | KMT2AMEN1ALOX15ALDH1A1KDM5B | |
| SCHEMBL28961125 | 0.72 | NAAA (0.55) | KMT2AMEN1ALOX15ALDH1A1MAPT | |
| SCHEMBL19302643 | 0.72 | HPGD (0.61) | ALDH1A1HPGD | |
| SCHEMBL23306676 | 0.72 | PBRM1 (0.55) | KMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1335850-A | Quinoline derivatives | SMITHKLINE BEECHMA PLC (GB) | 2002-02-13 | — | — | CN | disclosed |
| EP-1140946-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035919-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-06-22 | — | — | WO | disclosed |