Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.54 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241082 | 0.84 | SLC6A2 (0.71) | HRH3SLC6A2SLC6A4CARM1PRMT6 | |
| SCHEMBL941899 | 0.80 | SLC6A2 (0.79) | SLC6A2SLC6A4CARM1PRMT6TSHR | |
| SCHEMBL6427944 | 0.80 | MEN1 (0.61) | SLC6A2SLC6A4CARM1PRMT6TSHR | |
| SCHEMBL3540368 | 0.78 | SLC6A2 (0.63) | HRH3SLC6A2SLC6A4CARM1PRMT6 | |
| SCHEMBL13673491 | 0.78 | SLC6A2 (0.56) | SLC6A2SLC6A4CARM1PRMT6TSHR | |
| SCHEMBL15801112 | 0.77 | MAPT (0.61) | SLC6A2SLC6A4 | |
| SCHEMBL5889215 | 0.77 | ALDH1A1 (0.58) | SLC6A2SLC6A4TSHRNPC1RAB9A | |
| SCHEMBL2776292 | 0.77 | SLC6A2 (0.55) | SLC6A2SLC6A4TSHRCCR3 | |
| SCHEMBL2952169 | 0.77 | MEN1 (0.65) | SLC6A2SLC6A4 | |
| SCHEMBL29046166 | 0.76 | CARM1 (0.47) | SLC6A2SLC6A4CARM1PRMT6SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018734-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-04-06 | — | — | WO | disclosed |