Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11932064 | 0.87 | CFTR (0.61) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL7852629 | 0.85 | CFTR (0.46) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL7843306 | 0.85 | CFTR (0.46) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL822834 | 0.81 | CFTR (0.73) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL7855291 | 0.79 | HSP90AA1 (0.50) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL19010401 | 0.74 | CFTR (0.63) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL12715937 | 0.74 | LMNA (0.85) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL18161910 | 0.72 | CFTR (0.59) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL29672587 | 0.71 | CFTR (0.53) | NPSR1LMNACFTRGOPCMAPT | |
| SCHEMBL361852 | 0.71 | CFTR (0.53) | NPSR1LMNACFTRGOPCMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887349-B1 | Tetrahydroimidazo (2,1-a)isoquinoline derivatives | AKZO NOBEL NV (NL) | 2001-11-28 | — | — | EP | disclosed |
| US-5994366-A | PSYCHOLOGICAL DISORDERS | AKZO NOBEL NV (NL) | 1999-11-30 | — | — | US | disclosed |
| EP-0887349-A1 | Tetrahydroimidazo (2,1-a)isoquinoline derivatives | Akzo Nobel N.V. (NL) | 1998-12-30 | — | — | EP | disclosed |