Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.45 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7851258 | 0.90 | EGFR (0.44) | MALT1EGFRMAPTERBB2SCN9A | |
| SCHEMBL7854432 | 0.89 | BTK (0.45) | MALT1EGFRERBB3MAPTSCN9A | |
| SCHEMBL7844668 | 0.88 | EGFR (0.42) | MALT1EGFRMAPTERBB2SCN9A | |
| SCHEMBL7854183 | 0.87 | EGFR (0.43) | MALT1EGFRMAPTERBB2POLB | |
| SCHEMBL7855000 | 0.85 | EGFR (0.43) | MALT1EGFRMAPTERBB2SCN9A | |
| SCHEMBL7856240 | 0.83 | MALT1 (0.43) | MALT1EGFRERBB3MAPTERBB2 | |
| SCHEMBL7853478 | 0.83 | BTK (0.42) | MALT1EGFRERBB3MAPTSCN9A | |
| SCHEMBL7853525 | 0.82 | MCHR1 (0.47) | EGFRERBB3ERBB2KMO | |
| SCHEMBL7855396 | 0.82 | EGFR (0.42) | MALT1EGFRERBB3MAPTERBB2 | |
| SCHEMBL7853244 | 0.82 | HPGD (0.48) | MALT1EGFRERBB3MAPTERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163242-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055162-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |