Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852078 | 0.82 | MALT1 (0.45) | EGFRMALT1ERBB3SCN9AERBB2 | |
| SCHEMBL7853143 | 0.82 | MCHR1 (0.43) | EGFRMALT1ERBB3ERBB2 | |
| SCHEMBL7590899 | 0.80 | EGFR (0.62) | EGFRERBB2MAPT | |
| SCHEMBL7853478 | 0.79 | BTK (0.42) | EGFRMALT1ERBB3SCN9AMAPT | |
| SCHEMBL7854432 | 0.79 | BTK (0.45) | EGFRMALT1ERBB3SCN9AMAPT | |
| SCHEMBL7856240 | 0.78 | MALT1 (0.43) | EGFRMALT1ERBB3SCN9AERBB2 | |
| SCHEMBL8804523 | 0.77 | EGFR (0.48) | EGFRERBB3 | |
| SCHEMBL8804525 | 0.77 | EGFR (0.48) | EGFRERBB3 | |
| SCHEMBL7853525 | 0.77 | MCHR1 (0.47) | EGFRERBB3ERBB2 | |
| SCHEMBL7855000 | 0.75 | EGFR (0.43) | EGFRMALT1SCN9AERBB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163242-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055162-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |