Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 8/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7857100 | 0.92 | GNRHR (0.55) | GNRHRADORA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL7592330 | 0.87 | MEN1 (0.40) | GNRHRADORA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL7841825 | 0.85 | GNRHR (0.51) | GNRHRMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL7851652 | 0.84 | GNRHR (0.51) | GNRHRADORA2BMEN1KMT2ATP53 | |
| SCHEMBL7841358 | 0.84 | GNRHR (0.46) | GNRHRMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL7850711 | 0.84 | GNRHR (0.50) | GNRHR | |
| SCHEMBL7850471 | 0.82 | GNRHR (0.48) | GNRHRADORA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL7597400 | 0.82 | GNRHR (0.48) | GNRHRADORA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL7842945 | 0.82 | GNRHR (0.51) | GNRHR | |
| SCHEMBL7851919 | 0.82 | MAPT (0.43) | GNRHRMEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640606-B1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-07 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |
| EP-0640606-A1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |