Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 8/20 | 0.55 |
| ▸ | EDNRB | P24530 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852099 | 0.92 | GNRHR (0.52) | GNRHRMAPTADORA2BTP53POLB | |
| SCHEMBL7841825 | 0.87 | GNRHR (0.51) | GNRHRMAPTTP53POLBMEN1 | |
| SCHEMBL7851652 | 0.86 | GNRHR (0.51) | GNRHRADORA2BTP53POLBMEN1 | |
| SCHEMBL7855497 | 0.85 | GNRHR (0.45) | GNRHREDNRBMAPTALDH1A1MAPK1 | |
| SCHEMBL7851611 | 0.85 | GNRHR (0.49) | GNRHREDNRBMAPTADORA2BTP53 | |
| SCHEMBL7850334 | 0.84 | GNRHR (0.48) | GNRHREDNRBMAPTADORA2BTP53 | |
| SCHEMBL7850471 | 0.84 | GNRHR (0.48) | GNRHRMAPTADORA2BTP53POLB | |
| SCHEMBL7597400 | 0.84 | GNRHR (0.48) | GNRHREDNRBADORA2BTP53POLB | |
| SCHEMBL7850711 | 0.84 | GNRHR (0.50) | GNRHREDNRB | |
| SCHEMBL7854243 | 0.84 | GNRHR (0.47) | GNRHRADORA2BTP53POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640606-B1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-07 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |
| EP-0640606-A1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |