Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961208 | 0.91 | JAK3 (0.66) | JAK3SCN9AJAK1JAK2DOT1L | |
| SCHEMBL28068350 | 0.77 | JAK3 (0.67) | JAK3JAK1JAK2DOT1LLCK | |
| SCHEMBL28887147 | 0.77 | JAK3 (0.67) | JAK3JAK1JAK2DOT1LLCK | |
| SCHEMBL7842637 | 0.77 | JAK3 (0.54) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL6743217 | 0.76 | JAK3 (0.67) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL3951466 | 0.75 | JAK3 (0.71) | JAK3JAK1JAK2DOT1LLCK | |
| SCHEMBL2018758 | 0.74 | JAK3 (0.43) | JAK3SCN9AJAK1JAK2FFAR2 | |
| SCHEMBL2018756 | 0.74 | JAK3 (0.43) | JAK3SCN9AJAK1JAK2FFAR2 | |
| SCHEMBL3959625 | 0.73 | JAK3 (0.68) | JAK3JAK1JAK2DOT1LLCK | |
| SCHEMBL29869816 | 0.73 | ROCK2 (0.65) | JAK3JAK1JAK2AKT2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087971-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065909-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |