Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 10/20 | 0.52 |
| ▸ | TAS1R1 | Q7RTX1 | 10/20 | 0.52 |
| ▸ | TAS1R2 | Q8TE23 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SPTLC2 | O15270 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785279 | 1.00 | ALDH1A1 (0.54) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL803578 | 0.96 | ALDH1A1 (0.54) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL2818576 | 0.96 | ALDH1A1 (0.54) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL2818077 | 0.89 | ALDH1A1 (0.64) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL2818079 | 0.89 | ALDH1A1 (0.64) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL785625 | 0.88 | ALDH1A1 (0.57) | ALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL785162 | 0.88 | ALDH1A1 (0.57) | ALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL784965 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL484334 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL803549 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TAS1R3TAS1R1TAS1R2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| CN-103097354-A | Substituted benzamide compounds | GRUENENTHAL CHEMIE | 2013-05-08 | — | — | CN | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | ALDH1A1 1267/4885TAS1R3 202/4885TAS1R1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.