SCHEMBL7854079

SCHEMBL7854079

C[Si](C)(C)c1cccc(Cl)c1C(=O)NCc1ccc(C(F)(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.50
LSS P48449 1/20 0.48
KMT2A Q03164 3/20 0.47
ATM Q13315 1/20 0.47
MAPK14 Q16539 2/20 0.46
ALDH2 P05091 3/20 0.46
RORC P51449 1/20 0.44
MAPK7 Q13164 1/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
EPHX2 P34913 1/20 0.44
PPARG P37231 1/20 0.44
PPARA Q07869 1/20 0.44
MEN1 O00255 1/20 0.44
PLA2G1B P04054 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
GAA P10253 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL205506 0.87 MAPK14 (0.54) MAPTLSSKMT2AMAPK14ALDH2
SCHEMBL7855101 0.85 MAPK7 (0.59) MAPK14ALDH2MAPK7CYP3A4GAA
SCHEMBL7854551 0.85 MAPT (0.56) MAPTKMT2AALDH2LMNAPPARG
SCHEMBL10389072 0.83 ALDH2 (0.58) MAPTLSSKMT2AATMMAPK14
SCHEMBL7853247 0.82 L3MBTL1 (0.53) MAPTKMT2ALMNAHPGDMEN1
SCHEMBL7854522 0.80 KMT2A (0.46) KMT2AATMALDH2LMNAMEN1
SCHEMBL7856236 0.80 HPGD (0.42) ALDH2HPGD
SCHEMBL7854204 0.79 MEN1 (0.49) MAPTLSSKMT2APPARAMEN1
SCHEMBL7855604 0.77 MAPK14 (0.60) MAPK14HPGDCYP1A2CYP2D6CYP2C19
SCHEMBL29419149 0.77 LSS (0.51) LSSKMT2AMAPK14ALDH2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1088481-A2 Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 2001-04-04 EP disclosed
EP-0538231-A1 Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1993-04-21 EP disclosed