Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154462 | 0.79 | NOTUM (0.50) | MAPK1USP2POLBBRD4HSP90AA1 | |
| SCHEMBL6303368 | 0.78 | MYC (0.53) | MAPK1USP2POLBHSP90AA1KMT2A | |
| SCHEMBL28436731 | 0.77 | L3MBTL1 (0.56) | POLBHSP90AA1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL30637639 | 0.76 | NPC1 (0.46) | CDK2HSP90AA1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8610906 | 0.76 | NPC1 (0.46) | CDK2HSP90AA1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL30928942 | 0.76 | NPC1 (0.46) | CDK2HSP90AA1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL152899 | 0.74 | HSP90AA1 (0.50) | POLBHSP90AA1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL7854463 | 0.73 | PARP1 (0.41) | DOT1LHSP90AA1KMT2AALDH1A1HSP90AB1 | |
| SCHEMBL31483721 | 0.73 | HTT (0.64) | BRD4KMT2AL3MBTL1ALDH1A1HPGD | |
| SCHEMBL26417076 | 0.73 | HTT (0.64) | BRD4KMT2AL3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077927-A1 | NOVEL SUBSTITUTED CYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058495-A1 | NOVEL SUBSTITUTED CYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1999-11-18 | — | — | WO | disclosed |