Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303792 | 0.86 | LMNA (0.49) | LMNAPOLBSMN1; SMN2PKMKDM4E | |
| SCHEMBL3306024 | 0.85 | CHRM1 (0.51) | LMNAPOLBSMN1; SMN2PKMKDM4E | |
| SCHEMBL13174683 | 0.82 | POLB (0.52) | LMNAPOLBSMN1; SMN2PKMKDM4E | |
| SCHEMBL7581212 | 0.81 | PKM (0.43) | PKMKDM4ECHRM4GAA | |
| SCHEMBL30066393 | 0.81 | LMNA (0.49) | LMNAPOLBSMN1; SMN2CHRM4GAA | |
| SCHEMBL3311351 | 0.80 | SMN1; SMN2 (0.48) | LMNAPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL23125043 | 0.79 | LMNA (0.49) | LMNAPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21458714 | 0.78 | PKM (0.43) | LMNASMN1; SMN2PKMKDM4EALDH1A1 | |
| SCHEMBL13174685 | 0.78 | POLB (0.48) | LMNAPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL26984738 | 0.77 | LMNA (0.47) | LMNAPOLBSMN1; SMN2CHRM4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163242-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055162-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |