Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856343 | 1.00 | DPP4 (0.45) | DPP4SIRT6ALDH1A1GSK3BGAA | |
| SCHEMBL7198334 | 0.91 | MEN1 (0.46) | DPP4ALDH1A1GSK3BGAAMKNK1 | |
| SCHEMBL5099914 | 0.90 | BRD4 (0.44) | DPP4SIRT6ALDH1A1GAALMNA | |
| SCHEMBL5089316 | 0.87 | GSK3B (0.48) | DPP4ALDH1A1GSK3BGAALMNA | |
| SCHEMBL7026103 | 0.85 | GSK3B (0.45) | DPP4ALDH1A1GSK3BGAALMNA | |
| SCHEMBL27559770 | 0.83 | GSK3B (0.44) | DPP4ALDH1A1GSK3BGAALMNA | |
| SCHEMBL5093721 | 0.83 | GSK3B (0.45) | DPP4SIRT6ALDH1A1GSK3BGAA | |
| SCHEMBL7146519 | 0.83 | MAPT (0.53) | DPP4ALDH1A1GSK3BGAALMNA | |
| SCHEMBL6639575 | 0.83 | GSK3B (0.44) | DPP4ALDH1A1GSK3BGAALMNA | |
| SCHEMBL27541731 | 0.83 | KMT2A (0.48) | DPP4ALDH1A1GSK3BGAAMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |