Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086445 | 0.91 | ALDH1A1 (0.52) | MEN1KMT2ADPP4ALDH1A1CYP1A2 | |
| SCHEMBL7856343 | 0.91 | DPP4 (0.45) | DPP4ALDH1A1STAT6GSK3BMKNK1 | |
| SCHEMBL7856342 | 0.91 | DPP4 (0.45) | DPP4ALDH1A1STAT6GSK3BMKNK1 | |
| SCHEMBL6085442 | 0.89 | MAPT (0.43) | MEN1KMT2ADPP4ALDH1A1GSK3B | |
| SCHEMBL5089316 | 0.87 | GSK3B (0.48) | MEN1KMT2ADPP4ALDH1A1CYP1A2 | |
| SCHEMBL6085617 | 0.86 | STAT6 (0.45) | ALDH1A1STAT6GSK3BMERTKJAK2 | |
| SCHEMBL5101064 | 0.85 | KMT2A (0.43) | MEN1KMT2ADPP4ALDH1A1CYP1A2 | |
| SCHEMBL7026103 | 0.84 | GSK3B (0.45) | MEN1KMT2ADPP4ALDH1A1CYP1A2 | |
| SCHEMBL27559775 | 0.83 | GSK3B (0.48) | MEN1KMT2ADPP4ALDH1A1CYP1A2 | |
| SCHEMBL27570898 | 0.82 | MKNK1 (0.44) | DPP4ALDH1A1GSK3BMERTKMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |