Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856980 | 0.96 | OPRK1 (0.54) | OPRK1MAPK14USP30BRAFSMO | |
| SCHEMBL2979241 | 0.94 | OPRK1 (0.55) | OPRK1MAPK14USP30BRAFSMO | |
| SCHEMBL7806472 | 0.90 | OPRK1 (0.51) | OPRK1MAPK14USP30SMOGPR119 | |
| SCHEMBL2972096 | 0.89 | OPRK1 (0.58) | OPRK1MAPK14BRAFSMOGPR119 | |
| SCHEMBL6533594 | 0.89 | OPRK1 (0.56) | OPRK1MAPK14USP30BRAFSMO | |
| SCHEMBL7840065 | 0.87 | MAPK14 (0.59) | MAPK14BRAFRAF1 | |
| SCHEMBL7804552 | 0.86 | OPRK1 (0.54) | OPRK1MAPK14USP30SMOGPR119 | |
| SCHEMBL6476766 | 0.84 | OPRK1 (0.59) | OPRK1MAPK14USP30BRAFSMO | |
| SCHEMBL7853300 | 0.84 | OPRK1 (0.56) | OPRK1MAPK14BRAFSMO | |
| SCHEMBL7809442 | 0.83 | MAPK14 (0.52) | OPRK1MAPK14USP30SMOGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007980-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |