Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804552 | 0.93 | OPRK1 (0.54) | MAPK14SMOGPR119OPRK1USP30 | |
| SCHEMBL6476511 | 0.93 | MAPK14 (0.62) | MAPK14SMOGPR119OPRK1 | |
| SCHEMBL7806485 | 0.89 | MAPT (0.50) | MAPK14SMOTGFBR1MEN1KMT2A | |
| SCHEMBL7806472 | 0.89 | OPRK1 (0.51) | MAPK14SMOGPR119OPRK1USP30 | |
| SCHEMBL2972096 | 0.88 | OPRK1 (0.58) | MAPK14SMOGPR119OPRK1 | |
| SCHEMBL7856980 | 0.88 | OPRK1 (0.54) | MAPK14SMOGPR119OPRK1USP30 | |
| SCHEMBL6476766 | 0.87 | OPRK1 (0.59) | MAPK14SMOGPR119OPRK1USP30 | |
| SCHEMBL7805559 | 0.86 | OPRK1 (0.46) | MAPK14SMOOPRK1TGFBR1 | |
| SCHEMBL2979241 | 0.84 | OPRK1 (0.55) | MAPK14SMOOPRK1USP30 | |
| SCHEMBL7857012 | 0.83 | OPRK1 (0.51) | MAPK14SMOGPR119OPRK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |