Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10191767 | 0.90 | HRH3 (0.36) | HRH3GPR119 | |
| SCHEMBL864606 | 0.89 | GPR119 (0.38) | HRH3GPR119 | |
| SCHEMBL10191726 | 0.87 | GPR119 (0.39) | HRH3GPR119 | |
| SCHEMBL863863 | 0.86 | OTUD7B (0.37) | HRH3GPR119KCNH2 | |
| SCHEMBL864124 | 0.83 | OTUD7B (0.41) | GPR119 | |
| SCHEMBL10191763 | 0.83 | KDM4E (0.40) | HRH3 | |
| SCHEMBL10191787 | 0.83 | HRH3 (0.33) | HRH3GPR119 | |
| SCHEMBL10246786 | 0.82 | HRH3 (0.38) | HRH3KCNH2 | |
| SCHEMBL863262 | 0.82 | HRH3 (0.38) | HRH3 | |
| SCHEMBL863631 | 0.82 | CREBBP (0.39) | HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010144571-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-12-16 | — | — | WO | disclosed |