Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13416007 | 0.78 | HTT (0.45) | RAB9AMAPTNPC1KDM4EHSD17B10 | |
| SCHEMBL3425584 | 0.77 | MAPT (0.47) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL753210 | 0.73 | KDM4E (0.72) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL11298413 | 0.73 | MAPT (0.44) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL7864083 | 0.72 | HTT (0.44) | KDM4EHSD17B10ALDH1A1TERTHTT | |
| SCHEMBL6827675 | 0.72 | HSP90AA1 (0.40) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL12402387 | 0.72 | CYP2A6 (0.61) | MAPTKDM4ESMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL12680207 | 0.72 | ALOX5 (0.38) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL6850748 | 0.72 | CYP2A6 (0.60) | MAPTKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL10160902 | 0.72 | CYP2D6 (0.44) | RAB9AMAPTNPC1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514567-B2 | Oxazolidinone nicotinic acetylcholine receptor agonists | ASTRAZENECA AB (SE) | 2009-04-07 | — | — | US | disclosed |
| US-7514567-B2 | Oxazolidinone nicotinic acetylcholine receptor agonists | ASTRAZENECA AB (SE) | 2009-04-07 | — | — | US | disclosed |
| EP-1161438-A1 | 6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055168-A1 | 6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2000-09-21 | — | — | WO | disclosed |
| US-6054435-A | 6-O-substituted macrolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2000-04-25 | — | — | US | disclosed |