SCHEMBL7858113

SCHEMBL7858113

CCCOc1ccc(-c2ccc(CCc3ccc(OC)c(F)c3)c(F)c2)cc1F

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 1/20 0.46
S1PR1 P21453 1/20 0.41
NAAA Q02083 2/20 0.41
PDGFRB P09619 1/20 0.40
PDGFRA P16234 1/20 0.40
MGLL Q99685 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9664442 0.80 MAOB (0.48)
SCHEMBL9484389 0.79 MAPT (0.46) CYP17A1S1PR1PDGFRBPDGFRAMGLL
SCHEMBL10977756 0.78 S1PR1 (0.49) CYP17A1S1PR1KDM4EALDH1A1
SCHEMBL12447022 0.78 CSNK2A1 (0.46) S1PR1KDM4EALDH1A1
SCHEMBL9399243 0.78 SMN1; SMN2 (0.56) S1PR1
SCHEMBL10978980 0.77 CYP17A1 (0.46) CYP17A1S1PR1KDM4EALDH1A1
SCHEMBL9664301 0.76 RARB (0.47) KDM4EALDH1A1
SCHEMBL9398975 0.76 GLA (0.55) S1PR1
SCHEMBL10303023 0.76 CYP17A1 (0.47) CYP17A1S1PR1NAAAPDGFRBPDGFRA
SCHEMBL10974933 0.76 S1PR1 (0.53) CYP17A1S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6197217-B1 EXHIBIT A NEGATIVE DIELECTRIC ANISOTROPY VALUE, HAVE AN EXTREMELY HIGH VOLTAGE HOLDING RATIO AND A LOW THRESHOLD VOLTAGE, SMALL DEPENDENCY ON TEMPERATURE, HARDLY EXHIBIT SMECTIC PHASE; EXCELLENT IN MISCIBILITY WITH OTHER LC'S CHISSO CORPORATION (JP) 2001-03-06 US disclosed
EP-0959061-A1 3,3'-DIFLUOROBIPHENYL DERIVATIVES, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY ELEMENTS CHISSO CORPORATION (JP) 1999-11-24 EP disclosed