Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 5/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL917520 | 0.80 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL5685945 | 0.75 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL6545918 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7139408 | 0.74 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL11699947 | 0.72 | CHRNB2 (0.56) | CHRNB2CHRNA4OPRK1 | |
| SCHEMBL2903184 | 0.71 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3ESR1 | |
| SCHEMBL11703659 | 0.70 | CHRNB2 (0.54) | CHRNB2CHRNA4OPRK1 | |
| SCHEMBL11703811 | 0.70 | CHRNB2 (0.54) | CHRNB2CHRNA4OPRK1 | |
| SCHEMBL3162433 | 0.69 | ALDH1A1 (0.43) | CHRNB2CHRNA4ESR1ESR2 | |
| SCHEMBL29871375 | 0.69 | ALDH1A1 (0.43) | CHRNB2CHRNA4ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010036943-A1 | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines | PFIZER PRODUCTS INC. | 2001-11-01 | — | — | US | disclosed |