Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.48 |
| ▸ | PLK1 | P53350 | 3/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 4/20 | 0.44 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7858062 | 0.96 | REN (0.49) | RENPLK1CTSDAPLNR | |
| SCHEMBL10087705 | 0.94 | PLK1 (0.48) | RENPLK1CTSDAPLNR | |
| SCHEMBL464257 | 0.92 | PLK1 (0.49) | RENPLK1CTSDAPLNR | |
| SCHEMBL464254 | 0.89 | PLK1 (0.50) | RENPLK1CTSDAPLNR | |
| SCHEMBL15729655 | 0.85 | PLK1 (0.50) | RENPLK1CTSDAPLNR | |
| SCHEMBL15729438 | 0.84 | PLK1 (0.50) | RENPLK1CTSDAPLNR | |
| SCHEMBL20920291 | 0.83 | PLK1 (0.48) | RENPLK1CTSDAPLNR | |
| SCHEMBL20920292 | 0.83 | PLK1 (0.49) | RENPLK1CTSDAPLNR | |
| SCHEMBL17226098 | 0.82 | REN (0.61) | RENPLK1CTSD | |
| SCHEMBL15729660 | 0.81 | PLK1 (0.51) | RENPLK1CTSDAPLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132869-A2 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-11-18 | — | — | WO | disclosed |