Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.61 |
| ▸ | CTSD | P07339 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 3/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.49 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.49 |
| ▸ | TRHR | P34981 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852891 | 0.96 | REN (0.65) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL7842935 | 0.96 | REN (0.65) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL7849192 | 0.96 | REN (0.65) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL13470161 | 0.91 | REN (0.56) | RENCTSDPLK1TRHR | |
| SCHEMBL15729472 | 0.91 | REN (0.56) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL464364 | 0.89 | PLK1 (0.56) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL464377 | 0.87 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930126 | 0.87 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930164 | 0.87 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930127 | 0.87 | PLK1 (0.70) | RENPLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9175038-B2 | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2015-11-03 | — | — | US | disclosed |