Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.78 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | ANPEP | P15144 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL3217703 | 0.91 | PLAU (0.81) | PLAUDRD2DRD3ANPEPOPRK1 | |
| Benzene SCHEMBL299297 | 0.90 | PLAU (0.95) | PLAUDRD2DRD3ANPEPOPRK1 | |
| SCHEMBL896147 | 0.88 | PLAU (1.00) | PLAUDRD2DRD3ANPEPOPRK1 | |
| SCHEMBL30368725 | 0.88 | PLAU (1.00) | PLAUDRD2DRD3ANPEPOPRK1 | |
| SCHEMBL895905 | 0.88 | PLAU (1.00) | PLAUDRD2DRD3ANPEPOPRK1 | |
| SCHEMBL30038968 | 0.88 | PLAU (1.00) | PLAUDRD2DRD3ANPEPOPRK1 | |
| SCHEMBL42952 | 0.88 | PLAU (1.00) | PLAUDRD2DRD3ANPEPOPRK1 | |
| SCHEMBL29428767 | 0.88 | PLAU (1.00) | PLAUDRD2DRD3ANPEPOPRK1 | |
| Benzamide SCHEMBL6599407 | 0.86 | PLAU (0.68) | PLAUDRD2DRD3ANPEPOPRK1 | |
| Charcoal, Activated SCHEMBL6230334 | 0.86 | PLAU (0.95) | PLAUDRD2DRD3ANPEPOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119543-A1 | N-ARALKYLAMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000020376-A1 | N-ARALKYLAMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-04-13 | — | — | WO | claimed |