Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL29058151 | 1.00 | DGAT1 (0.42) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| Hydrogen Peroxide SCHEMBL28079587 | 0.97 | DGAT1 (0.43) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| SCHEMBL29121 | 0.93 | DGAT1 (0.46) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| Acetic Acid SCHEMBL28020931 | 0.90 | FFAR3 (0.44) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| SCHEMBL27351077 | 0.90 | DGAT1 (0.43) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| Methyl Alcohol SCHEMBL28820308 | 0.90 | DGAT1 (0.43) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| Ammonia Solution, Strong SCHEMBL9998492 | 0.90 | DGAT1 (0.43) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| Fluoride SCHEMBL2692246 | 0.90 | DGAT1 (0.43) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| SCHEMBL28114416 | 0.90 | DGAT1 (0.43) | DGAT1ELANEHDAC6HDAC1HDAC2 | |
| SCHEMBL7860268 | 0.85 | ELANE (0.38) | DGAT1ELANEHDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385013-B2 | Micro/nano materials, products obtained by covalently modifying surface of micro/nano materials with hydrophilic materials, and method for making same | CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD. (CN) | 2019-08-20 | — | — | US | disclosed |
| EP-3470443-A1 | MICRO/NANOMATERIAL, PRODUCT THEREOF WITH SURFACE COVALENTLY MODIFIED WITH HYDROPHILIC MATERIAL, AND MANUFACTURING METHOD | Chongqing Bolanying (BLY) Biotechnology Co., Ltd., China (CN) | 2019-04-17 | — | — | EP | disclosed |
| US-20190077746-A1 | MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME | CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD. (CN) | 2019-03-14 | — | — | US | disclosed |
| EP-0837070-B1 | SIALIC ACID DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2001-10-31 | — | — | EP | disclosed |
| US-6288041-B1 | Sialic acid derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |
| EP-0837070-A1 | SIALIC ACID DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077746-A1 | MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME | PHOSPHO1, PTMS, PAM | DGAT1 1190/4885ELANE 567/4885HDAC6 1257/4885 |
| US-10385013-B2 | Micro/nano materials, products obtained by covalently modifying surface of micro/nano materials with hydrophilic materials, and method for making same | PHOSPHO1, PTMS, PAM | DGAT1 1190/4885ELANE 567/4885HDAC6 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.