Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MTTP | P55157 | 14/20 | 0.46 |
| ▸ | APOB | P04114 | 9/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786248 | 1.00 | KDM4E (0.47) | KDM4EMTTPAPOBTRPV1FPR2 | |
| SCHEMBL904386 | 0.89 | MTTP (0.52) | MTTPAPOBFPR2 | |
| SCHEMBL904380 | 0.89 | MTTP (0.52) | MTTPAPOBFPR2 | |
| SCHEMBL904381 | 0.89 | MTTP (0.52) | MTTPAPOBFPR2 | |
| Hydrochloric Acid SCHEMBL2579600 | 0.88 | MTTP (0.51) | MTTPAPOBFPR2 | |
| Usistapide SCHEMBL29376869 | 0.84 | NPY2R (0.62) | MTTPAPOB | |
| Usistapide SCHEMBL803531 | 0.84 | NPY2R (0.62) | MTTPAPOB | |
| Usistapide SCHEMBL785394 | 0.84 | NPY2R (0.62) | MTTPAPOB | |
| Usistapide SCHEMBL803532 | 0.84 | NPY2R (0.62) | MTTPAPOB | |
| SCHEMBL12174424 | 0.84 | MTTP (0.51) | MTTPAPOBFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-22 | — | — | US | claimed |
| EP-2435406-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | Janssen Pharmaceutica, N.V. (BE) | 2012-04-04 | — | — | EP | disclosed |
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | MTTP, CETP, LIPC | KDM4E 635/4885MTTP 1/4885APOB 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.