Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 12/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL892815 | 0.90 | MTNR1A (0.56) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL7850083 | 0.86 | MTNR1A (0.52) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL892708 | 0.85 | MTNR1A (0.53) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL7856519 | 0.83 | SNCA (0.50) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL7860117 | 0.83 | LMNA (0.50) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL7857392 | 0.80 | MTNR1A (0.48) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL7859054 | 0.80 | MTNR1A (0.46) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL7856590 | 0.80 | SNCA (0.55) | MTNR1AMTNR1BSNCAABCG2 | |
| SCHEMBL7856585 | 0.80 | TRPV1 (0.60) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 | |
| SCHEMBL892580 | 0.76 | MTNR1A (0.55) | MTNR1AMTNR1BLMNASMN1; SMN2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010142801-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-12-16 | — | — | WO | disclosed |