Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 6/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.33 |
| ▸ | FAP | Q12884 | 3/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.33 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PEPD | P12955 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952359 | 0.91 | ELANE (0.36) | ELANEDPP4DPP7FAPDPP8 | |
| SCHEMBL6742899 | 0.87 | ELANE (0.33) | ELANE | |
| SCHEMBL7860575 | 0.79 | ELANE (0.41) | ELANE | |
| Hydrochloric Acid SCHEMBL6591724 | 0.79 | PEPD (0.34) | ELANEDPP4DPP7FAPDPP8 | |
| SCHEMBL7860595 | 0.79 | ELANE (0.46) | ELANE | |
| SCHEMBL10573364 | 0.78 | XIAP (0.38) | CYP2C19 | |
| SCHEMBL7860728 | 0.78 | ELANE (0.41) | ELANE | |
| Hydrochloric Acid SCHEMBL7882835 | 0.77 | L3MBTL1 (0.38) | DPP4DPP7FAPDPP8PREP | |
| Trifluoromethanesulfonic Acid SCHEMBL7286712 | 0.74 | HTT (0.34) | DPP4DPP7L3MBTL1ALDH1A1 | |
| SCHEMBL7960590 | 0.72 | ELANE (0.40) | ELANECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762887-B1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMA INC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-5972897-A | AN ANTIINFLAMMATORY AGENTS TREATING CYSTIC FIBROSIS AND EMPHYSEMA OR BOWEL DISEASES, A NEUTROPHIL ASSOCIATED INFLAMMATORY DISEASE, BRONCHITIS | MERRELL PHARMACEUTICALS INC. (US) | 1999-10-26 | — | — | US | disclosed |
| EP-0762887-A4 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMA INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0762887-A1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033478-A1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1995-12-14 | — | — | WO | disclosed |