Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 15/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860595 | 0.89 | ELANE (0.46) | ELANECMA1CTRC | |
| SCHEMBL7966452 | 0.83 | ELANE (0.41) | ELANECMA1KMT2AMEN1CTRC | |
| SCHEMBL8510794 | 0.82 | ELANE (0.41) | ELANECMA1KMT2AMEN1CTRC | |
| SCHEMBL7330747 | 0.79 | ELANE (0.39) | ELANECMA1KMT2AMEN1 | |
| SCHEMBL7329397 | 0.79 | ELANE (0.39) | ELANECMA1KMT2AMEN1 | |
| SCHEMBL7860987 | 0.78 | ELANE (0.37) | ELANE | |
| SCHEMBL7859515 | 0.77 | ELANE (0.41) | ELANECMA1KMT2A | |
| SCHEMBL7860727 | 0.77 | ELANE (0.55) | ELANECMA1 | |
| SCHEMBL7881751 | 0.73 | CTSL (0.43) | ELANECMA1KMT2AMEN1 | |
| SCHEMBL7853825 | 0.72 | ELANE (0.39) | ELANECMA1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762887-B1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMA INC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-5972897-A | AN ANTIINFLAMMATORY AGENTS TREATING CYSTIC FIBROSIS AND EMPHYSEMA OR BOWEL DISEASES, A NEUTROPHIL ASSOCIATED INFLAMMATORY DISEASE, BRONCHITIS | MERRELL PHARMACEUTICALS INC. (US) | 1999-10-26 | — | — | US | disclosed |
| EP-0762887-A4 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMA INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0762887-A1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033478-A1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1995-12-14 | — | — | WO | disclosed |